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Liposarcomas represent the single most common type of soft tissue sarcoma. Its abdominal localization is rare, occurring
in only 5% of cases. A 55 year old male was found to have a case of primary giant liposarcoma of the mesenterium
with a maximum diameter of 40 cm and weight of 9 kg. Computed tomography revealed the presence of a large mass
presenting a dishomogeneous density with an adipose component, probably of mesenteric origin. A xifopubic laparotomy
confirmed the presence of a pedunculated growth originating from the mesentery. The mass was removed and the histopathological
report noted a well differentiated sclerosing liposarcoma with the peritoneal liquid positive for malignant cells.
Surgery currently represents the only possibly curative therapy for this type of tumour but close long-term follow up and
accurate evaluation of the clinicopathologic parameters are needed.