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Jehovah’s Witnesses are a well-known patient demographic in medicine because of their religious-based refusal of bloodtransfusion. This case report outlines the treatment of a Jehovah’s Witness patient in need of an extensive cytoreductivesurgery due to a peritoneal carcinomatosis of ovarian origin. The surgeons carried out all the recommended surgical andanaesthetic measures concluding that extensive cytoreductive surgery on a Jehovah’s Witness is possible and that a com-plete cytoreduction can be safely performed.