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Sir Complex regional pain syndrome (CRPS) describes a diversity of painful conditions which usually follow trauma with nerve injury. CRPS type II is characterized by somatic and vegetative functional deterioration 1-4, with neuro-inflammatory pathogenesis 3.We would like to report our clinical experience with CRPS type II of the upper limb. In the last years, we observed that the lidocaine use was associated with CRPS onset, influencing the neuro-inflammatory mechanisms that underlie CRPS