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Neurofibromatosis (NF) is a relatively common disorderoccurring approximately in 1/3000 births (1, 2, 3).Bolande (4), first introduced the term of neurocristo-pathy to point out the common neural crest origin ofall involved tissues in NF. Although the involvement oftissues not derived from neural crest was reported (1, 5),the hypothesis that NF is a disorder of neural crest ori-gin could be well-founded yet because the alterated neu-ral crest derivates could be able to product disorders innot derived from neural crest tissues (1, 3). The mela-nocytes are derivates of neural crest too. They produceone of the most costant features in NF, the cafè au laitspots. Association between cutaneous melanoma and NFis reported in literature. However, although melanocytesclearly are involved in NF, the association of both thedisorders is not demonstrated and the correct incidenceof cutaneous melanoma in NF is unknown. We reportone case of a patient affected by cutaneous melanomaand NF.