Comparison of Flavonoids and Centella asiatica for the treatment of chronic anal fissure. A randomized clinical trial

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COD: 2873_28_05_2018_AOP Categorie: ,

Massimo Chiaretti, Danilo Alunni Fegatelli, Giancarlo Ceccarelli, Giovanna Angela Carru,
Giuseppe Pappalardo, Annalisa Italia Chiaretti

Ann Ital Chir, Digital Edition 2018; 7
Epub Ahead of Print – May 28

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AIMS: We aim to test and compare the effects of Flavonoids (Fs) and Centella asiatica (Ca), and the traditional treatment
to find out which best deals with healing time, bleeding and pain in the treatment of chronic Anal Fissure (AF).
Materials of Study: 98 outpatients were divided randomly into treated (either Fs or Ca) and control group. The control
group (Group C, n=32) received the traditional treatment along with the other two subgroups which were treated, additionally,
with Fs (Group A, n=30) or Ca (Group B, n=36). Patients were observed once weekly over 8 consecutive weeks.
RESULTS: The median time to stop bleeding in the group A was 1 week, in the Group B was 3 weeks and in the group
C was 4 weeks. There were significant differences between Groups in terms of time to end bleeding (A vs B: p-value=
0.022; A vs C: p-value<0.001; B vs C: p-value=0.070). As for pain score from baseline to the 2nd week were statistically different between Groups A and B on the one hand and Group C on the other hand (A vs C: p-value=0.004; B vs C: p-value 0.035). All patients healed within 8th week. DISCUSSION: Either patients treated with Fs or Ca experienced early pain disappearance. Fs and Ca did not show side effects CONCLUSIONS: The treatment with Fs is the most effective for bleeding. Patients additionally treated with either Fs or Ca experienced an earlier healing and disappearance of pain in comparison with patients underwent to the traditional treatment.