Comparison of endocrinological and cytokine response to trauma in laparoscopic and conventional appendectomy in patients with acute appendicitis

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COD: 10_2947_AOP Categorie: ,

Erol Pişkin, Mesut Özdedeoğlu, Bahtiyar Muhammedoğlu, Yiğit Mehmet Özgün, Anhmet Kuşdemir

Ann Ital Chir, 2019 90, 1: 68-71
Epub Ahead of Print – November 29

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PURPOSE: In this study, we compared the endocrine and cytokine reaction of the patients which laparoscopic and conventional
appendectomy was done for acute appendicitis.
MATERIALS AND METHOD: 50 patients who were operated for acute appendicitis in Ankara Atatürk Research and Training
Hospital between the dates December 2013 and February 2014 were enrolled and grouped as either laparoscopic or
conventional. Serum ACTH, IL-6 and CRP levels were obtained at induction of anesthesia and postoperative 6th hour.
RESULTS: There was no significant difference between the groups in terms of gender, co-morbidities, and perforation rate.
Preoperative ACTH levels were similar for both groups while it is significantly lower in postoperative period for laparoscopy
group. Moreover, IL-6 levels were also higher in postoperative period for conventional period compared to laparoscopy
group. Despite preoperative CRP value of the laparoscopic group was significantly higher than the conventional group,
postop values showed no statistical difference. The mean operation time of the laparoscopic appendectomy group was significantly
higher than the conventional group.
CONCLUSION: Laparoscopic appendectomy causes less metabolic and cytokine response than conventional surgery. ACTH
and IL-6 levels could be assessed to evaluate metabolic outcome of surgical intervention.

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