Bilateral prophylactic mastectomy in BRCA mutation carriers: what surgeons need to know


COD: 01_2019_01_3021 Categorie: ,

Gianluca Franceschini, Alba Di Leone, Daniela Terribile, Martin Alessandro Sanchez, Riccardo Masetti

Ann. Ital. Chir., 2019 90: 1-2

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Aim of this paper is to allows to analyze a topic of great
relevance and media interest such as the role of prophylactic
mastectomy in healthy women with BRCA
mutation proposing to the surgeons some useful informations
for decision-making.
Less than 15% of all breast cancers are associated with
germline genetic mutations. The majority of hereditary
breast tumors are due to mutations in BRCA1 and
BRCA2 genes that are responsible for only one third of
hereditary cases. The risk estimates are extremely heterogeneous
with a mean cumulative lifetime breast cancer
risk of approximately 72% in BRCA1 and 69% in
BRCA2 by age 80. The breast cancer is often bilateral
and multicentric in BRCA mutation carriers. BRCA1
carriers have earlier-onset disease, particularly before age
50 and are more likely to develop aggressive triple-negative
breast cancer than BRCA2 carriers or those who
are BRCA mutation negative.


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