Axillary metastases from occult breast cancer. Our experience


COD: 2212_28_02_2014 Categorie: ,

Alessandro Sanguinetti, Andrea Polistena, Giuseppe D’Ermo, Roberta Lucchini, Roberta Triola, Claudia Conti, Stefano Avenia, Giuseppe Cavallaro, Giorgio De Toma, Nicola Avenia

Ann. Ital. Chir.Published online (EP) 28 February 2014

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We report the case of a 63-year-old woman with occult breast cancer who presented with a hard metastatic nodule inthe left axilla. Although histology identified a metastatic carcinoma in the lymph nodes, numerous tests failed to detectthe primary tumor. Resected lymph node was positive for both estrogen and progesterone receptors, suggesting the breastas the site of the primary tumor. Left modified radical mastectomy was performed. Pathology revealed an invasive lob-ular carcinoma (2.5 x 2mm in size) with extensive lymphatic involvement, which strongly expressed both vascular endothe-lial growth factor-C (VEGF-C) and VEGF-D.