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Fournier’s Gangrene (FG) is an extremely serious condition of necrotizing soft tissue infection. The treatment of this critical condition is urgent but much debated, especially as regards the management of larger defects and wound closure, with various techniques being described in the current literature. Through a case series we aimed to present our surgical management of FG treated successfully with Negative Pressure Wound Therapy (NPWT) and performing a loop colostomy.