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The authors report on a case of voluminous perforated gastrointestinal stromal tumor (GIST) of small intestine and
make a review to the light of most recent clinicopathologic advancements. The first clinical manifestation as acute abdomen
due to their perforation extremely rare. Gastrointestinal stromal tumor (GIST) represent a rare group of multiforms
tumors with various biological behaviour.
Were identified in the past as leiomyomas, leiomyosarcomas or leiomyoblastomas, has been reclassificated on immunochemical
features, with a positive expression of Kit (CD117 antigen). Traditionally the prognostic factors of these tumour
are: mitotic rate, tumor size and anatomic site. The complete surgical resection and use of imatinib mesylate (Gleevec)
are the best available approach.
