Acute lower limb ischemia complicating pemetrexed and carboplatin combination chemotherapy for malignant pleural mesothelioma

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Serena Valerio
Umberto Marcello Bracale
Anna Maria Giribono
Emanuela Viviani
Federica Caioni
Luca Del Guercio

Abstract

Pemetrexed and Carboplatin are two well-known chemioterapic agents used for the treatment of many tumors, especially for lung cancer and mesothelioma. Peripheral ischemic events related to Pemetrexed and Carboplatin are rarely reported.
We herein report a case of lower limb acute ischemia related to combined treatment of Pemetrexed and Carboplatin. A 68-year-old woman was given the chemiotherapic treatment with combination of Pemetrexed and Carboplatin after  pleural resection for a malignant pleural mesothelioma. Immediately after the second cycle of treatment, the patient experienced  sudden acute left lower limb ischemia. Symptoms resolved after an intra-operative thrombolytic and spasmolytic therapy.

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How to Cite
Valerio, Serena, et al. “Acute Lower Limb Ischemia Complicating Pemetrexed and Carboplatin Combination Chemotherapy for Malignant Pleural Mesothelioma”. Annali Italiani Di Chirurgia, vol. 3, no. November, Nov. 2014, pp. 1-4, https://annaliitalianidichirurgia.it/index.php/aic/article/view/1245.
Section
Case Report