About recent developments of synthetic polymers for a suitable cell adhesion/growth support in tissue engineering-based either augmentation cystoplasty or neobladder

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COD: 01_2284_309-316 Categorie: ,

Contardo Alberti

Ann. Ital. Chir., 2014 85: 309-316

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Among the regenerative medicine technologies, the tissue engineering has emerged, in recent years, as a prominent tool,
particularly given the tremendous developments in the field of synthetic polymer-based scaffolds. Scaffold surface coatings
with either extracellular matrix (ECM) proteins or integrin-binding bioactive peptide sequences, such as RDG, proved
to be extremely useful to enhance cell adhesion and growth. Nevertheless, about it, excellent effects may be reached by
electrospinning-obtained nanofiber-structured synthetic polymer scaffold – such as polyurethane or polyethylene-terephthalate
electrospun nanofibers – without resorting to surface- coated adhesion proteins. As for bladder tissue engineering, properly
cell-seeded synthetic biomaterial-based scaffolds allow today timely chances to obtain constructs provided with specific
bladder native tissue-like both histological-immunohistochemical and functional-dynamic features. Recent bright advances
in the tissue engineering research, particularly in the area of materials science – together with increasing availability
of suitable bioreactors – and stem cell biology, make foreseeable, in the near future, further technological improvements
that might widen the clinical applications of bladder tissue engineering up to whole bladder replacement in radical tumor
surgery.

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