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Splenosis is a clinical condition characterized by the presence of ectopic splenic tissue in the abdominal cavity occurring after abdominal trauma or surgical procedure involving the spleen. We present a case of an 80-year-old Caucasian male who underwent splenectomy at the age of 36, with a prior diagnosis of cancer of the left kidney associated with a pancreatic neoformation. This study compare our case with similar published and reviev the Literature.