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Castleman’s disease or angiofollicular lymph node hyperplasia is a rare clinical entity, and may involve any parts of the body. Unicentric presentation of the disease is the most common presentation. Castleman’s disease of the pancreas that mimics a pancreatic neoplasm is more uncommon. We present a 38-year-old female patient with a one-month past history of abdominal pain. Imaging studies revealed hypervascular, 4 x 2 cm in size nodular mass localised in the pancreatic body. In FDG PET/CT, the pancreatic mass was FDG-avid. Laparoscopic enucleation of the lesion was performed. Histopathological study revealed unicentric form of Castleman’s disease, a hyaline vascular variant. Since these lesions are rare and resembling malignant tumors on computed tomography and angiography, we discuss the problems of diagnosing Castleman’s disease, together with the literature.
